ICOS Antikörper (PerCP-Cy5.5)

Produktnummer ABIN2660067

Dieses Hamster Monoklonal-Antikörper erkennt spezifisch ICOS in WB, IHC, FACS, IP, BR und Act. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ICOS Antikörper (PerCP-Cy5.5) (ABIN2660067)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reaktivität: Human, Maus, Ratte

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser ICOS Antikörper ist konjugiert mit PerCP-Cy5.5

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR), Activation (Act)

Klon: C398-4A

Produktdetails anti-ICOS Antikörper (PerCP-Cy5.5)

Kreuzreaktivität: Rhesusaffen, Schwein

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Andere Bezeichnung: CD278

Hintergrund: ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

Pathways: Cancer Immune Checkpoints